Meng Zhao
UIC
Halogenation chemistry has been developed for more than 100 years. But still today, significant challenges in halogenation chemistry remain, such as fluorination. We are interested in halogenation chemistry with a major focus on the synthesis of molecules, which can be used in pharmaceuticals, agrochemicals and materials.
In the poster, I presented three projects that I have been working on recently. The first project is about the olefin dichlorination reaction. Using SOCl2 and mCPBA combination, we can obtain dichlorination products from different types olefins including cis and trans olefins. The second project is about the fluorination of tertiary carbon centers. Simply using silver (II) fluoride in dichloroethane, tertiary bromides can be transferred to tertiary fluoride products. The third project is about the Meyer–Schuster rearrangement from propargylic alcohols to α-haloenones. This transformation is very useful because α-haloenone motif exists in many natural products. And our methodology gives a new way to synthesize this motif.
In the poster, I presented three projects that I have been working on recently. The first project is about the olefin dichlorination reaction. Using SOCl2 and mCPBA combination, we can obtain dichlorination products from different types olefins including cis and trans olefins. The second project is about the fluorination of tertiary carbon centers. Simply using silver (II) fluoride in dichloroethane, tertiary bromides can be transferred to tertiary fluoride products. The third project is about the Meyer–Schuster rearrangement from propargylic alcohols to α-haloenones. This transformation is very useful because α-haloenone motif exists in many natural products. And our methodology gives a new way to synthesize this motif.