Daniel Kohler
UIUC
A Pd-catalyzed oxidative amination reaction is presented. Alkenes are shown to react with acidic nitrogen heterocycles such as phthalimide and saccharin in the presence of a palladate catalyst to afford the anti-Markovnikov selective aminated product. Following trans-aminopalladation, a redox-relay process isomerizes the unsaturation to afford the thermodynamically most stable ketone or styrene products.