Darci Trader
Purdue
Through a recent screening campaign we discovered new small molecules that stimulate the 20S core particle of the proteasome. We are currently synthesizing and testing different derivatives to discover more potent small molecular stimulators of the 20S CP. The best molecules will the be tested in cell culture to see the affect that stimulating the 20S CP can have on toxic protein build-up, with a focus on alpha-synuclein.