Mariana Frojuello
UIC/Campinas
Preparation of novel heterocyclic building blocks containing suitable derivatisation sites is of great importance to the successful discovery of new bioactive molecules and drug candidates. In this context, triazole thiones have attracted much attention due to their interesting structural properties and versatile pharmacological activities. Among the technologies applied in the drug discovery process, flow chemistry have gained widespread acceptance as a powerful tool to overcome limitations regarding scale-up, reproducibility and safety. With this in mind, we report herein a telescoped synthesis for the fast obtention of 3-thio-1,2,4-triazoles.