Zhao Wu
UIUC
A general asymmetric route for the one-step synthesis of chiral β-branched amides and amines is reported. A highly enantioselective isomerization of allylamines, followed by enamine exchange, generates a common intermediate which is subsequently oxidized or reduced to the desired products. The enamine exchange allows for a rapid and modular synthesis of various motifs, including challenging β-diaryl and β-cyclic stereocenters such as biologically relevant (R)-Tolterodine and Terikalant.