Research Facilities
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Departmental and Research Resources Center Facilities

Lab and Fume Hoods

The group's research is performed in a 2000 ft2(200 m2) state-of-the-art lab-space.  Each group member performs his or her tasks in a six foot wide fume hood (left).  Safety is our primary concern: all chemicals are stored in cabinets (middle) with liquid compounds placed in plastic containers.  Solvents and odorous compounds are stored in special ventilated cabinets (right).

GC/MS and Chiral GC

Our group owns two Hewlett Packard/Agilent GC/MS systems. The first one is a 6890+ GC system combined with a 5973 mass selective detector. The MSD is capable of detecting mass from 1.6 to 800 amu. The GC system is comprised of an HP-5 column and an HP 7683 automatic liquid sampler which can accommodate up to 100 samples.

The second system includes an Agilent 7890 GC and an Agilent 5975C MSD. The measurement range of this triple axis MSD is from 1.6 to 1050 amu. The GC system is also comprised of an HP-5 column and an Agilent 7693 automatic liquid sampler with a 100-vial tray. Both two systems include Agilent's ChemStation to analyze and display sample results as well as a database which has over 150,000 mass spectra of known compounds.
Our group also owns an Agilent 7890 GC system equipped with two chiral capillary columns (a J&W cyclosil-b and a Supelco β-DEX 120)for the sake of resolution of stereoisomers. This system carries an Agilent 7693A automatic liquid sampler with a 16-vial tray.

HPLC

In addition to GC/MS for column chromatography, our lab also has two Gilson HPLC systems. The first one is an analytical system, equipped 321 pump and 152 UV/Vis detector. The second system is an semi-preparative system, comprised of a 305 pump, an 807 manometric module, a 112 UV detector and an FC204 fraction collector.

Solvent purification system

Our new solvent purification system allows to produce up to four anhydrous solvents and keep them at oxygen-free conditions ready for immediate use.

Glove Box

For working with various hygroscopic and other air-sensitive chemicals. The glove box is a 60 cubic foot, argon filled apparatus designed to keep chemicals isolated from oxygen, moisture, and other unwanted nuisances.  The box is equipped with a Sartorius analytical balance, IKA magnetic stirrer, a vacuum pump inlet, two side chambers (one for large unit entry, one for small), a Plexiglas clear window in the front, and two pairs of thick rubber gloves to allow the user to work within the box, all of which is necessary for synthetic operation within the glove box.

Rotary Evaporators

The group also possesses 9 rotary evaporators, which means there is a rotovap for every two people. Each unit is equipped with a variable temperature water bath and a 10 Torr teflon vacuum pump. The rotovaps allow for the rapid evaporation of solvents off of nonvolatile compounds.  To increase lab safety, each system is equipped with an additional condensation system for the evaporated solvent and all vapors not condensed are disposed of into fume hood.

CombiFlash Seperation System

For rapid separations, the group posesses a CombiflashRf automated chromatography system. This unit can be stocked with four different solvent types which can be programmed to mix to dynamically match any seperation protocol desired. Fractions are collected automatically by a robotic arm based on a variety of collection techniques, which include UV peak collection. The system uses factory packed, self contained high performance silica or alumina based media that are identified automatically by the system using individual Rf ID tags.

GeneVac Solvent Removal System

For efficient and effective evaporations, the group has the GeneVac solvent evaporator system. This device will remove solvent, in an inert atmosphere if needed, by centerfuging reaction mixtures to rapidly access products during the synthesis of libraries of molecules.

Kugelrohr

The group owns a B-580 Buchi glass oven distillation apparatus, also known as a kugelrohr.  The unit is comprised of the glass oven, a series of bulbs for distillations, a rotary unit for the rotation of these bulbs, and a vacuum adapter to perform distillations at reduced pressures.  The kugelrohr is used in the distillation of small amounts of compounds, where a simple distillation apparatus would be inefficient at best.  Using various vacuum pumps connected to the unit, far more effective distillations may be performed on small scale.

Fraction Collectors

To aid in the collection of samples from chromatography columns, we have several fraction collectors.  The machines are programmed to change test tubes automatically, allowing for other tasks to be performed while running the column.

Thermostate

The VWR thermostate allows for the maintaining of temperature reactions, both inside the thermostate and in the external reaction vessel, in the interval of -26°C to 260°C with an accuracy of 0.1°C.

Syringe Pump

The syringe pump can accommodate variable sizes of syringes and possesses the ability to control the actual rate that the liquid is added.  This is extremely useful for the slow addition of reactants to preserve an essential excess of one reactant versus another or to maintain extremely low concentrations of substrates.

Balances

In addition to regular lab balances, the group also has a Sartorius BP211 D analytical balance capable of measuring masses up to 210g.  The model has an accuracy of 0.01mg up to 80g and 0.1mg up to 210g.  We also have an Ohaus analytical balance with 0.1mg accuracy and can measure masses up to 120g.

Coffee Makers

Perhaps the most important and most frequently used piece of equipment in our chemistry lab is the coffee maker.  Fortunately, should tragedy one day strike our coffee maker, we also have an espresso maker as well. Also available are refrigerators, microwaves and water boilers, all invaluable pieces of machinery, as well.

 

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