Timothy A. Keiderling Professor Emeritus Department of Chemistry University of Illinois at Chicago 845 West Taylor St. (M/C 111) Chicago, Illinois 60607-7061 tel: (312)996-3156; FAX: 312-996-0431 e-mail: tak@uic.edu

EDUCATION

Ph.D., 1974; M.A., 1971: Physical Chemistry, Princeton University, Princeton, NJ
Thesis: "Electronic and Vibrational Spectroscopy of Uranium (IV) Borohydride"

B.S., 1969; Major: Chemistry, Minor: Physics, Math, LorasCollege, Dubuque, Iowa.
Thesis: "X-ray CrystalStructure of N(C2H5)4SbBr6"

RESEARCH EXPERIENCE

Current Position:

Professor of Chemistry - University of Illinois at Chicago- 1985 - present

2014 - Professor Emeritus, Chemistry, UIC

2003-04 - Associate Dean for Natural Sciences and Mathematics, College of LAS

1997-98, 1999-2000 - Acting Head, Department of Chemistry
Associate Professor - University of Illinois at Chicago - 1981-85
Assistant Professor - University of Illinois at Chicago Circle - 1976-81

Our research centers on experimental and theoretical research in spectroscopy applied to molecular structure problems. The major emphasis of the group centers on a variety of problems related to protein folding. We are studying peptides both experimentally and theoretically to model fundamental structural types in proteins and study stability, folding propensity and characteristic spectral patterns. Isotope editing has provided a site-specific method of interpreting structure-spectra relations. These theoretical studies are mostly quantum mechanically based but are now being extended with molecular dynamics simulations of peptide fluctuations and solvent variations. Our protein studies have moved away from the previous focus on development of novel statistically based, pattern recognition methods, for empirical secondary structure prediction from spectra to study of equilibrium and dynamic folding and unfolding processes with spectroscopic techniques. Time dependent spectral studies using stop-flow IR, CD and fluorescence and temperature jump methods are of growing importance in our work. Our current focus is on b-sheet dominant proteins, aggregation and fibrilization processes and protein-lipid membrane interactions.

Previous efforts on development of the vibrational circular dichroism (VCD) instrumentation, theoretical small molecule structural studies and empirical nucleic acid conformational studies have a smaller impact on our current research. Similarly, we do little with magnetic VCD or molecular Zeeman spectra, although good problems remain. There has been no recent work in the group on transition metal ligand field studies or on two-photon induced spectra. For more details, see the publication lists or descriptive pages on this site.

Previous Positions:

Visiting Professor Positions:

2011-12 - Guest Professor and Humboldt Awardee, Universitaet Konstanz, Fachbereich Chemie

- peptide dynamics, guest of Prof. Karin Hauser

2005- Guest Professor, University of Padova, Italy, Bioorganic Chemistry

- guest of Prof. Claudio Toniolo - Conformational studies of peptides with spectroscopy

2004-2005 (5 Months) - Guest Professor, University of Freiburg, Germany, Biophysics

- guest of Prof. Fritz Siebert - Time dependent IR studies of proteins

1994 - Senior Visitor - Oxford Centre for Molecular Sciences, Oxford University, England.

- guest of Prof. Christopher M.Dobson - NMR studies of peptide sequences taken from lysozyme and alpha-lactalbumin

1984 - Guest Professor, Max Planck Institut fuer Quantenoptik, Garching bei Muenchen, Germany.

- guest of Dr. Karl Kompa -MPI studies to study cold molecular ion beams

Postdoctoral:

Research Associate - University of Southern California, 1973 - 1976.
Research Director: Professor Philip Stephens.

Initial measurement of vibrational circular dichroism spectra for a variety of chiral organic molecules in solution and early theoretical modelling of the results. Measurement of the near infra-red CD of examples of iron-sulfur proteins. Measurement and analysis of intraconfigurational ligand field MCD spectra ofCs₂ZrCl₆:Ir⁺⁴. Instrumental development for infra-red CD and MCD spectroscopy.

Student Research:

Research and Teaching Assistant (Ph.D.) - Princeton University, 1969 -1973.
Research Advisor: Professor Elliot R. Bernstein (currently: Colorado State University)

Measured absorption, EPR andZeeman spectra of U(BH₄)₄ in mixed and pure crystal and vapor phases and interpreted data with vibronic coupling and ligand-field theories. Normal coordinate analysis,infra-red and Raman spectra of Hf(BH₄)₄[Hf(BD₄)₄]. Developed high vacuum synthetic andcrystal growing techniques and determined two crystal structures.

Research Assistant - Los Alamos Scientific Lab. Summer, 1969.
Supervisors; Drs. C. Smith and E. Dan Doughran.
Mass spectrometric studies of g-ray induced decomposition of C-N heterocycles.

Summer Trainee - Ames Lab. Iowa State University, Summer, 1968.
Research Director: Prof. Robert A. Jacobson.
Determined structure ofN(C₂H₅)₄SbBr₆ by single crystal x-raydiffraction

NSF Undergraduate Research - Loras College, Summer, 1967.
Research Director: Prof. Robert J. Reuland.
Synthesized and characterized magnesium-containing tungsten bronzes.

AWARDS/HONORS

Alexander von Humboldt Forschungspreis (Research Award) - Germany, 2011-13

Mentor of the Year, 2011, UIC Graduate College

Fellow of the Society for Applied Spectroscopy, awarded 2010

Guggenheim Fellow - Germany and Italy - 2004-05

Senior University Scholar, University of Illinois, 1991-94
Gordon Conference (Vibrational Spectroscopy) - elected Vice Chair (1990), Chair (1992).
Fulbright Senior Research Fellow - West Germany - 1984
UICC Faculty Summer Fellowship - 1977
National Science Foundation Graduate Fellow - 1969-72.

PROFESSIONAL SERVICE

Editorial Board, Proteins, Structure, Function, and Bioinformatics, a John Wiley Journal, 2006--

Editorial Board, Chirality, a John Wiley Journal, 2005--

Editorial Board, Analytical Biochemistry, an Elsevier Journal,  2005--

Editorial Board, Journal of Peptide Research, 2004-2006,

Editorial Advisory Board, Biopolymers, a John Wiley Journal, 2003--,

Editorial Board, BioSpectroscopy a John Wiley Journal 1994-99

Biophysical Society, -- Publications Committee, appointed--1998-2001, Membership Committee - 2006-12
Society for Applied Spectroscopy -- Secretary of Executive Comm. (elected) 2007-2009

- Tour Speaker, 2014 - Manchester, NH (St. Anselm Coll.), 2010-Milwaukee (U.Wisconsin), 1995 - St. Louis (Monsanto), Governing Board (elected) - 2002-2004; Membership Education Committee, 2002-04; Meggars Award Committee - 1999, 2000 (Chair)

Robert J. Gordon Recognition Symposium, Dynamics-Chemistry-Lasers, UIC, Organizer, April 2014

Philip J. Stephens Memorial Symposium, Chiroptical Spectroscopy, Univ. Southern California, Program Organizer and Chair, March 2013

International Conference on VOA, Steering Committee, (VOA-2) Albany, NY, 2010; (VOA-4) Baoding, China 2014

International Conference on Circular Dichroism and Chiral Discrimination, International Planning Committee: 2003, Budapest; 2005, Pensacola, FL; 2007, Groningen, NL; 2009 Brescia, IT; 2011, Oxford; 2013, Nashville; 2015, Sapporo

International Conference on Advanced Vibrational Spectroscopy (ICAVS-3), Program Committee, Lake Delavan, IL, 2005,

International Conference on FT Spectroscopy, Athens GA, 1997, Program Committee

University of the Air, Japan, video course segment and filmed lecture, 2004

Loras College, Department of Chemistry, Board of Visitors, 2010 -

Loyola University, Chicago, Chemistry External Review Committee, 2000
University of Missouri St. Louis, Chemistry Review Committee, External Member - 1999
Hunter College, Department of Chemistry Advisory Committee, 1987, 1997 (Chair)

NSF Proposal Review Panel - on site - Chemistry, April 2015

NSF Advisory Panel, Multi-User Biological Instrumentation, 1996
NIH Study Section: "BBCA"-Molecular and Cellular Biophysics, 1991-93 (member)
NIH Study Section: "BBCB"-Biophysical Chemistry, 2001 (ad hoc member)
NIH Special Study Section - Spectroscopic Instrumentation (RR), 1987, 1988
NIH Special Study Sections/Site Visits - 1985, 1988, 1989, 1991 (chairman), 1998, 2001
NSF Site Visit, Chicago State Univ. 1989

Last Update 12/08/15 -- TAK